Toshiaki Shimizu Selected Research

mizoribine

2/2019	Positive effects of single-daily high-dose mizoribine therapy after cyclophosphamide in young children with steroid-dependent nephrotic syndrome.
4/2014	The synergistic effect of mizoribine and a direct renin inhibitor, aliskiren, on unilateral ureteral obstruction induced renal fibrosis in rats.
9/2012	Maintenance therapy with single-daily, high-dose mizoribine after cyclophosphamide therapy for prepubertal boys with severe steroid-dependent nephrotic syndrome.
3/2011	Single daily high-dose mizoribine therapy for children with steroid-dependent nephrotic syndrome prior to cyclosporine administration.
2/2010	Effect of mizoribine in children with inflammatory bowel disease.
12/2005	High-dose mizoribine therapy for childhood-onset frequently relapsing steroid-dependent nephrotic syndrome with cyclosporin nephrotoxicity.
7/2002	Effect of mizoribine on IL-6 release by peripheral blood mononuclear cells.

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Toshiaki Shimizu Research Topics

Disease

33	Infections 06/2021 - 02/2002
16	Neoplasms (Cancer) 12/2021 - 11/2004
15	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 01/2010
15	Birth Weight (Birth Weights) 02/2020 - 10/2004
14	Inflammation (Inflammations) 01/2022 - 05/2008
14	Ulcerative Colitis 01/2021 - 10/2003
12	Nephrotic Syndrome (Syndrome, Nephrotic) 02/2019 - 12/2005
12	Seizures (Absence Seizure) 09/2016 - 11/2009
7	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 08/2017 - 02/2008
6	Crohn Disease (Crohn's Disease) 01/2021 - 01/2004
6	Hypersensitivity (Allergy) 01/2021 - 07/2006
6	Pancreatitis 12/2020 - 02/2008
6	Sepsis (Septicemia) 01/2020 - 01/2007
6	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 01/2020 - 04/2005
6	Colitis 10/2019 - 10/2003
6	Brain Diseases (Brain Disorder) 04/2017 - 06/2010
5	Pediatric ulcerative colitis 01/2022 - 12/2011
5	Fever (Fevers) 12/2021 - 05/2010
5	Food Hypersensitivity (Food Allergy) 01/2021 - 01/2010
4	Fibrosis (Cirrhosis) 01/2022 - 11/2009
4	Liver Cirrhosis (Hepatic Cirrhosis) 10/2021 - 02/2009
4	Abdominal Pain (Pain, Abdominal) 02/2021 - 11/2014
4	Diarrhea 04/2019 - 02/2007
4	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 11/2004
4	Chronic Hepatitis C 01/2016 - 11/2009
4	Biliary Atresia 05/2015 - 04/2002
4	IGA Glomerulonephritis (IGA Nephropathy) 01/2013 - 07/2002
3	Insulin Resistance 02/2022 - 09/2012
3	Body Weight (Weight, Body) 02/2022 - 12/2009
3	Virus Diseases (Viral Diseases) 12/2021 - 01/2014
3	Septic Shock (Toxic Shock Syndrome) 01/2021 - 01/2017
3	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 09/2020 - 10/2015
3	Disease Progression 04/2020 - 12/2014
3	Liver Diseases (Liver Disease) 01/2019 - 09/2011
3	Fetal Growth Retardation (Intrauterine Growth Retardation) 01/2018 - 12/2009
3	Nocturnal Enuresis (Bedwetting) 10/2017 - 12/2013
3	Partial Epilepsies (Epilepsy, Partial) 04/2016 - 06/2010
3	type 2C Congenital disorder of glycosylation 04/2014 - 09/2012
3	Atherosclerosis 05/2013 - 05/2008
3	Vesico-Ureteral Reflux (Vesicoureteral Reflux) 07/2009 - 05/2003

Drug/Important Bio-Agent (IBA)

12	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/2015 - 12/2005
11	SteroidsIBA 10/2019 - 01/2007
10	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2003
8	Biological ProductsIBA 01/2021 - 01/2012
8	Phenobarbital (Luminal)FDA Link 09/2016 - 10/2010
8	CytokinesIBA 11/2014 - 04/2002
7	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 10/2004
7	mizoribineIBA 02/2019 - 07/2002
6	LeptinIBA 02/2022 - 07/2003
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 04/2004
6	InterferonsIBA 01/2022 - 08/2010
6	Pharmaceutical PreparationsIBA 01/2021 - 11/2005
6	Indicators and Reagents (Reagents)IBA 06/2019 - 11/2003
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017 - 12/2002
6	Anticonvulsants (Antiepileptic Drugs)IBA 11/2015 - 06/2010
6	Messenger RNA (mRNA)IBA 01/2014 - 12/2002
6	Fatty Acids (Saturated Fatty Acids)IBA 03/2011 - 04/2002
5	EnzymesIBA 01/2022 - 02/2008
5	Polymyxin B (Aerosporin)FDA LinkGeneric 06/2021 - 05/2016
5	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 02/2006
5	Clarithromycin (Biaxin)FDA LinkGeneric 12/2020 - 02/2002
5	Interleukin-6 (Interleukin 6)IBA 01/2020 - 01/2010
5	Immunoglobulin E (IgE)IBA 04/2019 - 01/2010
5	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018 - 12/2002
5	Rituximab (Mabthera)FDA Link 08/2017 - 03/2010
5	AntigensIBA 03/2017 - 01/2004
4	Immunoglobulin G (IgG)IBA 12/2021 - 04/2005
4	Immunosuppressive Agents (Immunosuppressants)IBA 01/2021 - 07/2002
4	Infliximab (Remicade)FDA Link 01/2021 - 01/2017
4	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 11/2020 - 12/2013
4	Oxygen (Dioxygen)IBA 01/2020 - 12/2010
4	Bile Acids and Salts (Bile Acids)IBA 05/2019 - 08/2009
4	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 05/2012
4	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 03/2003
4	Asparaginase (Elspar)FDA Link 08/2017 - 02/2008
4	Insulin-Like Growth Factor I (IGF-1)IBA 01/2017 - 01/2010
4	HMGB1 Protein (HMG1)IBA 01/2016 - 01/2007
4	Ribavirin (Virazole)FDA LinkGeneric 01/2016 - 11/2009
4	Mycophenolic Acid (Cellcept)FDA LinkGeneric 04/2015 - 01/2007
4	Docosahexaenoic AcidsIBA 12/2010 - 10/2007
3	C-Reactive ProteinIBA 01/2022 - 05/2008
3	Prednisolone (Predate)FDA LinkGeneric 01/2021 - 04/2010
3	Kazal Pancreatic Trypsin InhibitorIBA 12/2020 - 01/2019
3	Tacrolimus (Prograf)FDA LinkGeneric 10/2019 - 12/2015
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 02/2019 - 10/2008
3	CreatinineIBA 06/2018 - 08/2014
3	Methylprednisolone FDA LinkGeneric 04/2017 - 03/2010
3	AdiponectinIBA 01/2016 - 10/2010
3	AntibodiesIBA 08/2015 - 06/2012
3	AlbuminsIBA 08/2014 - 01/2010
3	Insulin (Novolin)FDA Link 01/2013 - 06/2010
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2010 - 01/2010
3	PPAR gammaIBA 10/2010 - 02/2008

Therapy/Procedure

49	Therapeutics 06/2022 - 07/2002
10	Drug Therapy (Chemotherapy) 06/2019 - 06/2004
5	Aftercare (After-Treatment) 01/2020 - 03/2003
4	Hemoperfusion 06/2021 - 05/2016
3	Enteral Nutrition (Feeding, Tube) 02/2020 - 10/2006
3	Liver Transplantation 12/2015 - 09/2011
3	Fontan Procedure (Fontan Operation) 12/2011 - 10/2003